Cerdelga

Adult Dosing .

Dosage forms:  CAP: 84 mg

Gaucher dz, type 1

[CYP2D6 extensive metabolizers]

Dose: 84 mg PO bid; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap

[CYP2D6 intermediate metabolizers]

Dose: 84 mg PO bid; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap

[CYP2D6 poor metabolizers]

Dose: 84 mg PO qd; Info: if switching from another enzyme replacement tx, start w/ previous enzyme replacement dose 24h after last admin; do not open/dissolve cap

renal dosing

[CYP2D6 extensive metabolizers]

CrCl <15: avoid use

HD/PD: avoid use

[CYP2D6 intermediate or poor metabolizers]

renal impairment: avoid use

HD/PD: avoid use

hepatic dosing

[CYP2D6 extensive metabolizers]

Child-Pugh Class A: recommendations may vary based on concomitant drugs, see drug interactions; Child-Pugh Class B or C: contraindicated

[CYP2D6 intermediate metabolizers]

hepatic impairment: contraindicated

[CYP2D6 poor metabolizers]

hepatic impairment: contraindicated

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.