Zerbaxa

Adult Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total ceftolozane + tazobactam amt; 1.5 g ceftolozane/tazobactam contains 1 g ceftolozane + 0.5 g tazobactam

intra-abdominal infections, complicated

[1.5 g IV q8h x4-14 days]

Info: give w/ metronidazole 500 mg PO/IV q8h; duration varies by infection site/severity

UTI, complicated

[1.5 g IV q8h x7 days]

pneumonia, hospital-acquired or ventilator-assoc.

[3 g IV q8h x7 days]

Info: may extend duration based on clinical response; refer to IDSA guidelines

renal dosing

[complicated UTI or intra-abdominal infections]

CrCl 30-50: 750 mg q8h; CrCl 15-29: 375 mg q8h; CrCl <15: not defined; ESRD: 750 mg x1, then 150 mg q8h

HD: 750 mg x1, then 150 mg q8h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

[pneumonia, hospital-acquired or ventilator-assoc.]

CrCl 30-50: 1.5 g q8h; CrCl 15-29: 750 mg q8h; CrCl <15: not defined; ESRD: 2.25 g x1, then 450 mg q8h

HD: 2.25 g x1, then 450 mg q8h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total ceftolozane + tazobactam amt; 1.5 g ceftolozane/tazobactam contains 1 g ceftolozane + 0.5 g tazobactam

intra-abdominal infections, complicated

[90 mg/kg/day IV divided q8h x5-14 days]

Max: 1.5 g/dose; Info: give w/ metronidazole 30 mg/kg/day PO/IV divided q8h; duration varies by infection site/severity

UTI, complicated

[90 mg/kg/day IV divided q8h x7-14 days]

Max: 1.5 g/dose

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[no adjustment]