Lumakras

Adult Dosing .

Dosage forms:  TAB: 120 mg, 240 mg, 320 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

KRAS G12C-mutated non-small cell lung CA, locally advanced or metastatic

[960 mg PO qd]

Info: for patients who have received at least 1 prior tx; do not cut/crush/chew, but may disperse tab in water

KRAS G12C-mutated colorectal CA, metastatic

[960 mg PO qd]

Info: for patients who have received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based tx; use w/ panitumumab; may cont. as monotherapy if panitumumab permanently D/C'd; do not cut/crush/chew, but may disperse tab in water

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.