Prezcobix

Adult Dosing .

Dosage forms:  TAB: 675 mg/150 mg, 800 mg/150 mg

HIV infection

[800 mg/150 mg PO qd]

Info: for tx-naive patients or tx-experienced patients without darunavir resistance-associated substitutions; give with food

HIV post-exposure prophylaxis, nonoccupational (off-label)

[800 mg/150 mg PO qd]

Info: part of multi-drug regimen; give with food; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: avoid use

Peds Dosing .

Dosage forms:  TAB: 675 mg/150 mg, 800 mg/150 mg

HIV infection

[3 yo and older, 25-39 kg]

Dose: 675 mg/150 mg PO qd; Info: for tx-naive patients or tx-experienced patients without darunavir resistance-associated substitutions; give with food

[3 yo and older, >40 kg]

Dose: 800 mg/150 mg PO qd; Info: for tx-naive patients or tx-experienced patients without darunavir resistance-associated substitutions; give with food

HIV post-exposure prophylaxis, nonoccupational (off-label)

[>40 kg]

Dose: 800 mg/150 mg PO qd; Info: part of multi-drug regimen; give with food; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance