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amphetamine
generic
Black Box Warnings .
Abuse, Misuse, and Addiction
CNS stimulants have high potential for abuse and misuse, can lead to substance use disorder, including addiction; misuse and abuse can result in overdose and death, risk incr. with higher doses or unapproved administration methods; assess risk for abuse, misuse, and addiction before prescribing and throughout tx; educate patients and families about risks and proper drug storage and disposal; monitor frequently for signs/symptoms of abuse, misuse, and addiction during tx
Adult Dosing .
Dosage forms: TAB: 5 mg, 10 mg; ER ODT: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg
Special Note
- [equivalency or interchangeability info]
- Info: amphetamine ER products not interchangeable; do not substitute on a mg to mg basis; retitrate if switching between products
ADHD
- [immediate-release form]
- Dose: 5-40 mg/day PO divided qd-tid; Start: 5 mg PO qam or bid, may incr. by 5 mg/day qwk; Info: give divided doses at 4-6h intervals; doses >40 mg/day rarely more effective
- [extended-release form]
- Dose: 12.5 mg ER PO qam
narcolepsy
- [5-60 mg/day PO divided qd-tid]
- Start: 10 mg PO qam, may incr. by 10 mg/day qwk; Info: give divided doses at 4-6h intervals
weight management, short-term tx
- [15-30 mg/day PO divided tid]
- Info: for patients with obesity; give 30-60min before meals
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 5 mg, 10 mg; ER ODT: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg
Special Note
- [equivalency or interchangeability info]
- Info: amphetamine ER products not interchangeable; do not substitute on a mg to mg basis; retitrate if switching between products
ADHD
- [immediate-release form, 3-5 yo]
- Dose: 2.5-40 mg/day PO divided qd-tid; Start: 2.5 mg PO qam, may incr. by 2.5 mg/day qwk; Info: give divided doses at 4-6h intervals; doses >40 mg/day rarely more effective
- [immediate-release form, 6 yo and older]
- Dose: 5-40 mg/day PO divided qd-tid; Start: 5 mg PO qam or bid, may incr. by 5 mg/day qwk; Info: give divided doses at 4-6h intervals; doses >40 mg/day rarely more effective
- [extended-release form, 6-12 yo]
- Dose: 6.3-18.8 mg ER PO qam; Start: 6.3 mg ER PO qam, incr. by 3.1-6.3 mg/day qwk; Max: 18.8 mg/day ER
- [extended-release form, 13-17 yo]
- Dose: 6.3-12.5 mg ER PO qam; Start: 6.3 mg ER PO qam, incr. by 3.1-6.3 mg/day qwk; Max: 12.5 mg/day ER
narcolepsy
- [6-12 yo]
- Dose: 5-60 mg/day PO divided qd-tid; Start: 5 mg PO qam, may incr. by 5 mg/day qwk; Info: give divided doses at 4-6h intervals
- [12 yo and older]
- Dose: 5-60 mg/day PO divided qd-tid; Start: 10 mg PO qam, may incr. by 10 mg/day qwk; Info: give divided doses at 4-6h intervals
weight management, short-term tx
- [12 yo and older]
- Dose: 15-30 mg/day PO divided tid; Info: for patients with obesity; give 30-60min before meals
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]