Cresemba

Adult Dosing .

Dosage forms:  CAP: 74.5 mg, 186 mg; INJ: various

aspergillosis, invasive

[372 mg PO/IV q24h]

Start: 372 mg PO/IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

mucormycosis, invasive

[372 mg PO/IV q24h]

Start: 372 mg PO/IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  CAP: 74.5 mg, 186 mg; INJ: various

aspergillosis, invasive

[IV form, 1-2 yo, <18 kg]

Dose: 15 mg/kg/dose IV q24h; Start: 15 mg/kg/dose IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose

[IV form, 3 yo and older, <37 kg]

Dose: 10 mg/kg/dose IV q24h; Start: 10 mg/kg/dose IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose

[IV form, 3 yo and older, >37 kg]

Dose: 372 mg IV q24h; Start: 372 mg IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose

[PO form, 6 yo and older, 16-17 kg]

Dose: 149 mg PO q24h; Start: 149 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

[PO form, 6 yo and older, 18-24 kg]

Dose: 223.5 mg PO q24h; Start: 223.5 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

[PO form, 6 yo and older, 25-31 kg]

Dose: 298 mg PO q24h; Start: 298 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

[PO form, 6 yo and older, >32 kg]

Dose: 372 mg PO q24h; Start: 372 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

mucormycosis, invasive

[IV form, 1-2 yo, <18 kg]

Dose: 15 mg/kg/dose IV q24h; Start: 15 mg/kg/dose IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose

[IV form, 3 yo and older, <37 kg]

Dose: 10 mg/kg/dose IV q24h; Start: 10 mg/kg/dose IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose

[IV form, 3 yo and older, >37 kg]

Dose: 372 mg IV q24h; Start: 372 mg IV q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose

[PO form, 6 yo and older, 16-17 kg]

Dose: 149 mg PO q24h; Start: 149 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

[PO form, 6 yo and older, 18-24 kg]

Dose: 223.5 mg PO q24h; Start: 223.5 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

[PO form, 6 yo and older, 25-31 kg]

Dose: 298 mg PO q24h; Start: 298 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

[PO form, 6 yo and older, >32 kg]

Dose: 372 mg PO q24h; Start: 372 mg PO q8h x6 doses; Info: begin maint. dose 12-24h after final loading dose; do not open cap; may mix IV powder in 5 mL water and give PO

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined