Select a medication above to begin.
Strensiq
asfotase alfa
Black Box Warnings .
Hypersensitivity Rxn
life-threatening rxns incl. anaphylaxis have occurred; anaphylaxis has occurred during early tx and after extended tx duration; admin. where appropriate medical support incl. cardiopulmonary resuscitation equip. available; D/C immediately and start appropriate tx if severe rxn occurs; counsel pts on s/sx and to seek immediate medical attention if they occur at any time
Adult Dosing .
Dosage forms: INJ: 18 mg per 0.45 mL, 28 mg per 0.7 mL, 40 mg per mL, 80 mg per 0.8 mL
Special Note
- [dosing clarification]
- Info: do not use 80 mg/0.8 mL vial if wt <40 kg; lower systemic exposure w/ 80 mg/0.8 mL vial (100 mg/mL) compared to lower concentration vials (40 mg/mL) and lower exposure may not be adequate if wt <40 kg
hypophosphatasia, perinatal or infantile-onset
- [2 mg/kg/dose SC 3x/wk]
- Alt: 1 mg/kg/dose SC 6x/wk; Info: may give up to 3 mg/kg/dose SC 3x/wk if no response
hypophosphatasia, juvenile-onset
- [2 mg/kg/dose SC 3x/wk]
- Alt: 1 mg/kg/dose SC 6x/wk
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ: 18 mg per 0.45 mL, 28 mg per 0.7 mL, 40 mg per mL, 80 mg per 0.8 mL
Special Note
- [dosing clarification]
- Info: do not use 80 mg/0.8 mL vial if wt <40 kg; lower systemic exposure w/ 80 mg/0.8 mL vial (100 mg/mL) compared to lower concentration vials (40 mg/mL) and lower exposure may not be adequate if wt <40 kg
hypophosphatasia, perinatal or infantile-onset
- [2 mg/kg/dose SC 3x/wk]
- Alt: 1 mg/kg/dose SC 6x/wk; Info: may give up to 3 mg/kg/dose SC 3x/wk if no response
hypophosphatasia, juvenile-onset
- [2 mg/kg/dose SC 3x/wk]
- Alt: 1 mg/kg/dose SC 6x/wk
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]