Select a medication above to begin.
Kanuma
sebelipase alfa
Black Box Warnings .
Hypersensitivity Reaction
life-threatening reactions including anaphylaxis have occurred; anaphylaxis has occurred during early tx and after extended tx duration; administer where appropriate medical support including cardiopulmonary resuscitation equip. available; D/C immediately and start appropriate tx if severe reaction occurs; counsel patients on signs/symptoms and to seek immediate medical attention if they occur at any time
Adult Dosing .
Dosage forms: INJ
lysosomal acid lipase deficiency
- [1-3 mg/kg/dose IV q2wk]
- Start: 1 mg/kg/dose IV q2wk, then may incr. to 3 mg/kg/dose IV q2wk; Info: consider premed with antipyretic, antihistamine if hypersensitivity reaction
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
lysosomal acid lipase deficiency, rapidly progressive
- [1 mo and older]
- Dose: 1-5 mg/kg/dose IV qwk; Start: 1 mg/kg/dose IV qwk, then may incr. to 3 mg/kg/dose IV qwk, then may incr. to 5 mg/kg/dose IV qwk; Info: for patients with disease presenting within 6mo of birth; consider premed with antipyretic, antihistamine if hypersensitivity reaction
lysosomal acid lipase deficiency, non-rapidly progressive
- [1 mo and older]
- Dose: 1-3 mg/kg/dose IV q2wk; Start: 1 mg/kg/dose IV q2wk, then may incr. to 3 mg/kg/dose IV q2wk; Info: consider premed with antipyretic, antihistamine if hypersensitivity reaction
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]