Nuwiq

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approximately 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV q12-24h for at least 1 day until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor level 20-40%

[bleeding episode, moderate or major]

Dose: individualize dose IV q12-24h x3-4 days or until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor level 30-60%

[bleeding episode, life threatening]

Dose: individualize dose IV q8-24h until hemostasis and bleeding risk resolved; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor level 60-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop, then repeat dose IV q24h for at least 1 day until healing complete; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level 30-60%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then continue q8-24h for at least 7 days after healing complete; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level 80-100% preop and until healing complete, then desired factor VIII level 30-60%

[routine bleeding prophylaxis]

Dose: 30-40 units/kg/dose IV qod; Info: adjust dose based on clinical response

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approximately 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor, 2 yo and older]

Dose: individualize dose IV q12-24h for at least 1 day until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor level 20-40%

[bleeding episode, moderate or major, 2 yo and older]

Dose: individualize dose IV q12-24h x3-4 days or until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor level 30-60%

[bleeding episode, life threatening, 2 yo and older]

Dose: individualize dose IV q8-24h until hemostasis and bleeding risk resolved; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor level 60-100%

[bleeding prophylaxis, minor surgery, 2 yo and older]

Dose: individualize dose IV x1 preop, then repeat dose IV q24h for at least 1 day until healing complete; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level 30-60%

[bleeding prophylaxis, major surgery, 2 yo and older]

Dose: individualize dose IV x1 preop, then continue q8-24h for at least 7 days after healing complete; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level 80-100% preop and until healing complete, then desired factor VIII level 30-60%

[routine bleeding prophylaxis, 2-11 yo]

Dose: 30-50 units/kg/dose IV qod; Alt: 30-50 units/kg/dose IV 3x/wk; Info: adjust dose based on clinical response

[routine bleeding prophylaxis, 12 yo and older]

Dose: 30-40 units/kg/dose IV qod; Info: adjust dose based on clinical response

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]