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Vraylar
cariprazine
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly patients on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Suicidality
incr. suicidality risk in peds and young adult patients in short-term studies; observe all antidepressant-treated patients for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication with prescriber; safety and efficacy not established in peds patients
Adult Dosing .
Dosage forms: CAP: 0.5 mg, 0.75 mg, 1.5 mg, 3 mg, 4.5 mg, 6 mg; CAP (schizophrenia or manic/mixed bipolar disorder 7-day starter pack): 1.5 mg x1 and 3 mg x6
schizophrenia
- [1.5-6 mg PO qd]
- Start: 1.5 mg PO qd x1 day, then may incr. to 3 mg PO qd; Max: 6 mg/day; Info: may adjust dose in 1.5 mg or 3 mg increments; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, manic/mixed
- [3-6 mg PO qd]
- Start: 1.5 mg PO qd x1 day, then incr. to 3 mg PO qd; Max: 6 mg/day; Info: may adjust dose in 1.5 mg or 3 mg increments; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, depressive
- [1.5-3 mg PO qd]
- Start: 1.5 mg PO qd x14 days, then may incr. to 3 mg PO qd; Max: 3 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
major depressive disorder, adjunct tx
- [1.5-3 mg PO qd]
- Start: 1.5 mg PO qd x14 days, then may incr. to 3 mg PO qd; Max: 3 mg/day; Info: use with antidepressant; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: CAP: 0.5 mg, 0.75 mg, 1.5 mg, 3 mg, 4.5 mg, 6 mg; CAP (schizophrenia or manic/mixed bipolar disorder 7-day starter pack): 1.5 mg x1 and 3 mg x6
schizophrenia
- [13 yo and older]
- Dose: 1.5-4.5 mg PO qd; Start: 0.5 mg PO qd x2 days, then incr. to 1.5 mg PO qd x2 days, then may incr. to 3 mg PO qd on day 5 and to 4.5 mg PO qd on day 8; Max: 4.5 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, manic/mixed
- [10 yo and older]
- Dose: 3-4.5 mg PO qd; Start: 0.5 mg PO qd x2 days, then incr. to 1.5 mg PO qd x2 days, then to 3 mg PO qd x3 days, then may incr. to 4.5 mg PO qd; Max: 4.5 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined