Venclexta

Adult Dosing .

Dosage forms:  TAB: 10 mg, 50 mg, 100 mg; TAB (CLL/SLL 4-wk starter pack): 10 mg x14, 50 mg x7, and 100 mg x21

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing including toxicity-related dose adjustments

AML, newly diagnosed

[combo with azacitidine or decitabine]

Dose: 100 mg PO qd on day 1, then 200 mg PO qd on day 2, then 400 mg PO qd on day 3 as part of ramp-up dosing schedule, then 400 mg PO qd starting day 4; Info: for patients 75 yo and older, or who are ineligible for intensive induction chemo due to comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose; give with food; do not cut/crush/chew tab

[combo with low-dose cytarabine]

Dose: 100 mg PO qd on day 1, then 200 mg PO qd on day 2, then 400 mg PO qd on day 3, then 600 mg PO qd on day 4 as part of ramp-up dosing schedule, then 600 mg PO qd starting day 5; Info: for patients 75 yo and older, or who are ineligible for intensive induction chemo due to comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose; give with food; do not cut/crush/chew tab

CLL/SLL

[monotherapy]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6; Info: give with food; do not cut/crush/chew tab

[combo with acalabrutinib]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6 until wk 48; Start: on cycle 3 day 1 of acalabrutinib ; Info: give with food; do not cut/crush/chew tab

[combo with obinutuzumab]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6 until wk 45; Start: on cycle 1 day 22 of obinutuzumab; Info: give with food; do not cut/crush/chew tab

[combo with rituximab]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6 until wk 109; Info: start rituximab on wk 6 after receiving venetoclax 400 mg/day dose x7 days and continue venetoclax tx x24mo after initiating rituximab; give with food; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: decr. usual dose by 50%

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.