Cabometyx

Adult Dosing .

Dosage forms:  TAB: 20 mg, 40 mg, 60 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ cabozantinib capsules; do not substitute on a mg to mg basis

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >3wk before elective surgery or invasive dental procedure, restart >2wk after major surgery when wound fully healed

renal cell CA, advanced

[previously treated dz, monotherapy]

Dose: 60 mg PO qd; Info: for pts who had received at least 1 prior anti-angiogenic tx; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[first-line tx, combo w/ nivolumab]

Dose: 40 mg PO qd; Info: give at least 1h before or 2h after meals; do not cut/crush/chew tab

hepatocellular CA, previously treated

[60 mg PO qd]

Info: for pts who have received sorafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

differentiated thyroid CA, locally advanced or metastatic

[60 mg PO qd]

Info: for pts w/ progressive dz after VEGFR-targeted tx, and who are radioactive iodine-refractory or ineligible; give at least 1h before or 2h after meals; do not cut/crush/chew tab

neuroendocrine tumors, unresectable locally advanced or metastatic

[60 mg PO qd]

Info: for previously treated, well-differentiated pancreatic or extra-pancreatic dz; give at least 1h before or 2h after meals; do not cut/crush/chew tab

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class B: decr. usual start dose by 20 mg; Child-Pugh Class C: avoid use

Peds Dosing .

Dosage forms:  TAB: 20 mg, 40 mg, 60 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ cabozantinib capsules; do not substitute on a mg to mg basis

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >3wk before elective surgery or invasive dental procedure, restart >2wk after major surgery when wound fully healed

differentiated thyroid CA, locally advanced or metastatic

[12 yo and older, <40 kg]

Dose: 40 mg PO qd; Info: for pts w/ progressive dz after VEGFR-targeted tx, and who are radioactive iodine-refractory or ineligible; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[12 yo and older, >40 kg]

Dose: 60 mg PO qd; Info: for pts w/ progressive dz after VEGFR-targeted tx, and who are radioactive iodine-refractory or ineligible; give at least 1h before or 2h after meals; do not cut/crush/chew tab

neuroendocrine tumors, unresectable locally advanced or metastatic

[12 yo and older, <40 kg]

Dose: 40 mg PO qd; Info: for previously treated, well-differentiated pancreatic or extra-pancreatic dz; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[12 yo and older, >40 kg]

Dose: 60 mg PO qd; Info: for previously treated, well-differentiated pancreatic or extra-pancreatic dz; give at least 1h before or 2h after meals; do not cut/crush/chew tab

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class B: decr. usual dose by 20 mg; Child-Pugh Class C: avoid use