Vonvendi

Adult Dosing .

Dosage forms:  INJ

von Willebrand disease

[bleeding episode, minor]

Dose: 40-50 units/kg/dose IV x1, then 40-50 units/kg/dose IV q8-24h; Info: give 1st dose with factor VIII if FVIII:C level is <40% or unknown; dose, duration varies by site/severity of bleeding, severity of disease

[bleeding episode, major]

Dose: 50-80 units/kg/dose IV x1, then 40-60 units/kg/dose IV q8-24h x2-3 days; Info: give 1st dose with factor VIII if FVIII:C level is <40% or unknown; individualize dose to maintain trough VWF:RCo >50%; dose, duration varies by site/severity of bleeding, severity of disease

[bleeding prophylaxis, minor surgery]

Dose: 25-30 units/kg/dose IV x1 preop, then individualize dose IV q12-48h for at least 48h; Start: within 1h before surgery; Info: may give one additional preop dose 12-24h before surgery; give 1h preop dose with factor VIII if FVIII:C level is <30; maintain trough VWF:RCo and factor VIII levels >30% up to 72h post-surgery; dose, duration varies by site/severity of bleeding, severity of disease; see pkg insert for alternative loading dose calculation based on patient in vivo recovery

[bleeding prophylaxis, major surgery]

Dose: 40-60 units/kg/dose IV x1 preop, then individualize dose IV q12-48h for at least 72h; Start: within 1h before surgery; Info: may give one additional preop dose 12-24h before surgery; give 1h preop dose with factor VIII if FVIII:C level is <60; maintain trough VWF:RCo and factor VIII levels >50% up to 72h, then >30% after 72h post-surgery; dose, duration varies by site/severity of bleeding, severity of disease; see pkg insert for alternative loading dose calculation based on patient in vivo recovery

[bleeding prophylaxis, emergency surgery]

Dose: 40-60 units/kg/dose IV x1 preop; Start: within 1h before surgery; Info: give with factor VIII if FVIII:C level is <40-50 for minor surgery or <80-100 for major surgery; dose, duration varies by site/severity of bleeding, severity of disease; see pkg insert for alternative dose calculation based on patient in vivo recovery

[routine bleeding prophylaxis]

Dose: 40-60 units/kg/dose IV 2x/wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

von Willebrand disease

[bleeding episode, minor]

Dose: 40-50 units/kg/dose IV x1, then 40-50 units/kg/dose IV q8-24h; Info: give 1st dose with factor VIII if FVIII:C level is <40% or unknown; dose, duration varies by site/severity of bleeding, severity of disease

[bleeding episode, major]

Dose: 50-80 units/kg/dose IV x1, then 40-60 units/kg/dose IV q8-24h x2-3 days; Info: give 1st dose with factor VIII if FVIII:C level is <40% or unknown; individualize dose to maintain trough VWF:RCo >50%; dose, duration varies by site/severity of bleeding, severity of disease

[bleeding prophylaxis, minor surgery]

Dose: 25-30 units/kg/dose IV x1 preop, then individualize dose IV q12-48h for at least 48h; Start: within 1h before surgery; Info: may give one additional preop dose 12-24h before surgery; give 1h preop dose with factor VIII if FVIII:C level is <30; maintain trough VWF:RCo and factor VIII levels >30% up to 72h post-surgery; dose, duration varies by site/severity of bleeding, severity of disease; see pkg insert for alternative loading dose calculation based on patient in vivo recovery

[bleeding prophylaxis, major surgery]

Dose: 40-60 units/kg/dose IV x1 preop, then individualize dose IV q12-48h for at least 72h; Start: within 1h before surgery; Info: may give one additional preop dose 12-24h before surgery; give 1h preop dose with factor VIII if FVIII:C level is <60; maintain trough VWF:RCo and factor VIII levels >50% up to 72h, then >30% after 72h post-surgery; dose, duration varies by site/severity of bleeding, severity of disease; see pkg insert for alternative loading dose calculation based on patient in vivo recovery

[bleeding prophylaxis, emergency surgery]

Dose: 40-60 units/kg/dose IV x1 preop; Start: within 1h before surgery; Info: give with factor VIII if FVIII:C level is <40-50 for minor surgery or <80-100 for major surgery; dose, duration varies by site/severity of bleeding, severity of disease; see pkg insert for alternative dose calculation based on patient in vivo recovery

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]