Select a medication above to begin.
Vemlidy
tenofovir alafenamide
Black Box Warnings .
Hepatitis B Exacerbation
severe acute exacerbations of hepatitis may occur in HBV-infected patients when D/C tenofovir; monitor hepatic fxn closely for at least several months after D/C tenofovir; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 25 mg
hepatitis B infection, chronic
- [25 mg PO qd]
- Info: for pts w/ compensated liver dz; give w/ food
hepatitis B infection prophylaxis, perinatal transmission (off-label)
- [25 mg PO qd]
- Start: at 28-32 wk gestation; Info: for pregnant pts w/ HBV DNA >200,000; 1st-line agent; give w/ food; D/C between birth to 3mo postpartum
HIV infection (off-label)
- [25 mg PO qd]
- Info: give w/ food
HIV post-exposure prophylaxis (off-label)
- [25 mg PO qd]
- Info: part of multi-drug regimen; give w/ food; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables
renal dosing
- [see below]
- CrCl <15: avoid use
- HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A: no adjustment; Child-Pugh Class B or C: not defined
Peds Dosing .
- Dosage forms: TAB: 25 mg
hepatitis B infection, chronic
- [6 yo and older, >25 kg]
- Dose: 25 mg PO qd; Info: for pts w/ compensated liver dz; give w/ food
hepatitis B infection prophylaxis, perinatal transmission (off-label)
- [25 mg PO qd]
- Start: at 28-32 wk gestation; Info: for pregnant pts w/ HBV DNA >200,000; 1st-line agent; give w/ food; D/C between birth to 3mo postpartum
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance