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ofloxacin
generic
Black Box Warnings .
Disabling, Potentially Irreversible Serious Reactions
fluoroquinolones associated with tendinitis/tendon rupture, peripheral neuropathy, and CNS effects that may occur together; tendinitis/tendon rupture may occur during tx or months after tx D/C; incr. tendinitis/tendon rupture risk in all ages; risk further incr. in older patients >60 yo, patients taking corticosteroids, and patients with kidney, heart, or lung transplant; D/C immediately and avoid fluoroquinolone use in patients with these serious reactions
Avoid in Myasthenia Gravis
fluoroquinolones may exacerbate muscle weakness in patients with myasthenia gravis
Reserve Fluoroquinolone Use
for patients with no alternative tx options for acute bacterial exacerbation of chronic bronchitis or uncomplicated UTI
Adult Dosing .
Dosage forms: TAB: 200 mg, 300 mg, 400 mg
infections, bacterial
- [200-400 mg PO q12h]
- Info: dose, duration varies with infection type, severity
prostatitis
- [300 mg PO q12h x6wk]
UTI, uncomplicated
- [200 mg PO q12h x3-7 days]
- Info: for patients with no alternative tx options; give x3 days if cystitis; refer to IDSA guidelines
leprosy (Hansen disease), multibacillary (off-label)
- [patients who cannot take clofazimine]
- Dose: 400 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 12mo in refractory cases
- [patients who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
leprosy (Hansen disease), paucibacillary (off-label)
- [patients who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
typhoid fever (off-label)
- [400 mg PO bid x7-14 days]
renal dosing
- [see below]
- CrCl 20-50: give usual dose q24h; CrCl <20: give usual dose x1, then give 50% usual dose q24h
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- cirrhosis: max 400 mg/24h
Peds Dosing .
- Dosage forms: TAB: 200 mg, 300 mg, 400 mg
leprosy (Hansen disease), multibacillary (off-label)
- [15 yo and older, patients who cannot take clofazimine]
- Dose: 400 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 12mo in refractory cases
- [15 yo and older, patients who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
leprosy (Hansen disease), paucibacillary (off-label)
- [15 yo and older, patients who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
typhoid fever (off-label)
- [20 mg/kg/dose PO bid x10 days]
- Max: 400 mg/dose
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance