tiopronin

Adult Dosing .

Dosage forms:  TAB: 100 mg; DR TAB: 100 mg, 300 mg

cystinuria, severe homozygous

[individualize dose PO tid]

Start: 800 mg/day PO divided tid; Info: consider lower start dose in patients with severe toxicity history with penicillamine; adjust dose to maintain urinary cystine levels <250 mg/L; give IR form at least 1h before or 2h after meals

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 100 mg; DR TAB: 100 mg, 300 mg

cystinuria, severe homozygous

[>20 kg]

Dose: individualize dose PO tid; Start: 15 mg/kg/day PO divided tid; Max: 50 mg/kg/day; Info: consider lower start dose in patients with severe toxicity history with penicillamine; adjust dose to maintain urinary cystine levels <250 mg/L; give IR form at least 1h before or 2h after meals

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]