Kisqali Femara Co-Pack

Adult Dosing .

Dosage forms:  TAB (200 mg dose pack): ribociclib 200 mg x21 and letrozole 2.5 mg x28; TAB (400 mg dose pack): ribociclib 200 mg x42 and letrozole 2.5 mg x28; TAB (600 mg dose pack): ribociclib 200 mg x63 and letrozole 2.5 mg x28

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

hormone receptor-positive HER2-negative breast CA

[high-risk stage II or III early disease, adjuvant tx]

Dose: ribociclib 400 mg PO qam + letrozole 2.5 mg PO qam on days 1-21 of 28-day cycle, then letrozole 2.5 mg PO qam on days 22-28 of 28-day cycle x3y; Info: give w/ LHRH agonist in pre/perimenopausal patients or male patients; do not cut/crush/chew tab

[advanced or metastatic disease, initial tx]

Dose: ribociclib 600 mg PO qam + letrozole 2.5 mg PO qam on days 1-21 of 28-day cycle, then letrozole 2.5 mg PO qam on days 22-28 of 28-day cycle; Info: give w/ LHRH agonist in pre/perimenopausal patients or male patients; do not cut/crush/chew tab

renal dosing

[ribociclib component]

severe impairment: start 200 mg qam

HD/PD: not defined

[letrozole component]

CrCl >10: no adjustment; CrCl <10: not defined

HD/PD: not defined

hepatic dosing

[ribociclib component, early disease]

hepatic impairment: no adjustment

[ribociclib component, advanced or metastatic disease]

Child-Pugh Class B or C: start 400 mg qam

[letrozole component]

cirrhosis/Child-Pugh Class C: give usual dose q48h

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.