Nityr

Adult Dosing .

Dosage forms:  TAB: 2 mg, 5 mg, 10 mg

hereditary tyrosinemia, type 1

[1-2 mg/kg/dose PO qd]

Start: 0.5 mg/kg/dose PO bid, incr. to 0.75 mg/kg/dose PO bid if detectable blood or urine succinylacetone after 4wk, then may give 1-2 mg/kg/dose PO qd if undetectable blood and urine succinylacetone after at least 4wk on current dose; Max: 2 mg/kg/day; Info: use in combo w/ dietary restriction of tyrosine, phenylalanine

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 2 mg, 5 mg, 10 mg

hereditary tyrosinemia, type 1

[<5 yo]

Dose: 0.5-1 mg/kg/dose PO bid; Start: 0.5 mg/kg/dose PO bid, incr. to 0.75 mg/kg/dose PO bid if detectable blood or urine succinylacetone after 4wk; Max: 2 mg/kg/day; Info: use in combo w/ dietary restriction of tyrosine, phenylalanine

[5 yo and older]

Dose: 1-2 mg/kg/dose PO qd; Start: 0.5 mg/kg/dose PO bid, incr. to 0.75 mg/kg/dose PO bid if detectable blood or urine succinylacetone after 4wk, then may give 1-2 mg/kg/dose PO qd if undetectable blood and urine succinylacetone after at least 4wk on current dose; Max: 2 mg/kg/day; Info: use in combo w/ dietary restriction of tyrosine, phenylalanine

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]