Ozempic

Adult Dosing .

Dosage forms:  TAB: 1.5 mg, 4 mg, 9 mg; INJ (pen): 2 mg per 3 mL, 4 mg per 3 mL, 8 mg per 3 mL

Special Note

[prescribing info]

Info: see Wegovy for FDA-approved weight management dosing

[strength clarification]

Info: 2 mg per 3 mL pen delivers 0.25 mg or 0.5 mg per injection; 4 mg per 3 mL pen delivers 1 mg per injection; 8 mg per 3 mL pen delivers 2 mg per injection

[equivalency or interchangeability info]

Info: semaglutide 1.5 mg, 4 mg, 9 mg tabs not interchangeable with 3 mg, 7 mg, 14 mg tabs; do not substitute on a mg to mg basis

diabetes mellitus, type 2

[SC route, semaglutide-naive patients]

Dose: 0.5-2 mg SC qwk; Start: 0.25 mg SC qwk x4wk, then incr. to 0.5 mg SC qwk, then may incr. to 1 mg SC qwk after at least 4wk, then may incr. to 2 mg SC qwk after at least 4wk; Max: 2 mg/wk; Info: give doses >48h apart

[PO route, semaglutide-naive patients]

Dose: 4-9 mg PO qam; Start: 1.5 mg PO qam x30 days, then incr. dose to 4 mg PO qam; Info: may incr. dose to 9 mg PO qam after at least 30 days on 4 mg PO qam; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[PO route, conversion from semaglutide 7 mg PO qam]

Dose: 4 mg PO qam; Start: day after last 7 mg dose; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[PO route, conversion from semaglutide 14 mg PO qam]

Dose: 9 mg PO qam; Start: day after last 14 mg dose; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[PO route, conversion from semaglutide 0.5 mg SC qwk]

Dose: 4-9 mg PO qam; Start: 1wk after last injection; Info: give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

cardiovascular event risk reduction - DM type 2 patients

[SC route, semaglutide-naive patients]

Dose: 0.5-2 mg SC qwk; Start: 0.25 mg SC qwk x4wk, then incr. to 0.5 mg SC qwk, then may incr. to 1 mg SC qwk after at least 4wk, then may incr. to 2 mg SC qwk after at least 4wk if additional glycemic control needed; Max: 2 mg/wk; Info: for patients with established cardiovascular disease; give doses >48h apart

[PO route, semaglutide-naive patients]

Dose: 4-9 mg PO qam; Start: 1.5 mg PO qam x30 days, then incr. dose to 4 mg PO qam; Info: for patients at high risk; may incr. dose to 9 mg PO qam after at least 30 days on 4 mg PO qam if additional glycemic control needed; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[PO route, conversion from semaglutide 7 mg PO qam]

Dose: 4 mg PO qam; Start: day after last 7 mg dose; Info: for patients at high risk; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[PO route, conversion from semaglutide 14 mg PO qam]

Dose: 9 mg PO qam; Start: day after last 14 mg dose; Info: for patients at high risk; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

[PO route, conversion from semaglutide 0.5 mg SC qwk]

Dose: 4-9 mg PO qam; Start: 1wk after last injection; Info: for patients at high risk; give on empty stomach with up to 4 oz water >30min before food/drink/med; do not cut/crush/chew/dissolve tab

kidney disease progression and cardiovascular death risk reduction - DM type 2 patients with CKD

[1 mg SC qwk]

Start: 0.25 mg SC qwk x4wk, then incr. to 0.5 mg SC qwk, then incr. to 1 mg SC qwk after at least 4wk; Max: 2 mg/wk; Info: may incr. dose to 2 mg SC qwk after at least 4wk on 1 mg SC qwk if additional glycemic control needed; give doses >48h apart

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.