Select a medication above to begin.
Biktarvy
bictegravir/ emtricitabine/ tenofovir alafenamide
Black Box Warnings .
Hepatitis B Exacerbation
severe acute HBV exacerbations in HBV/HIV co-infected pts when D/C products containing emtricitabine or tenofovir; monitor hepatic fxn closely for at least several months in HBV/HIV co-infected pts who D/C bictegravir/emtricitabine/tenofovir alafenamide; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 50 mg/200 mg/25 mg
HIV infection
- [50 mg/200 mg/25 mg PO qd]
- Info: do not crush/chew tab, but may split tab
HIV post-exposure prophylaxis (off-label)
- [50 mg/200 mg/25 mg PO qd]
- Info: do not crush/chew tab, but may split tab; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables
renal dosing
- [tx-naive pts]
- CrCl <30: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD: avoid use; PD: not defined
- [virologically-suppressed pts]
- CrCl <30: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD: no adjustment, on dialysis days admin. after dialysis; supplement not defined; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: TAB: 30 mg/120 mg/15 mg, 50 mg/200 mg/25 mg
HIV infection
- [14-24 kg]
- Dose: 30 mg/120 mg/15 mg PO qd; Info: do not crush/chew tab, but may split tab
- [>25 kg]
- Dose: 50 mg/200 mg/25 mg PO qd; Info: do not crush/chew tab, but may split tab
renal dosing
- [tx-naive pts]
- CrCl <30: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD: avoid use; PD: not defined
- [virologically-suppressed pts]
- CrCl <30: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD: not defined, consider adult renal dosing for guidance; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined