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Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo)
coagulation factor Xa (recombinant), inactivated
Black Box Warnings .
Thromboembolic and Ischemic Events, Cardiac Arrest, and Sudden Deaths
serious and life-threatening arterial and venous thromboembolic events, ischemic events, incl. MI and ischemic stroke, cardiac arrest, and sudden deaths have occurred; monitor for thromboembolic events and initiate anticoagulation when medically appropriate; monitor for s/sx preceding cardiac arrest and tx as needed
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = coagulation factor Xa (recombinant), inactivated-zhzo
apixaban reversal
- [last apixaban dose up to 5 mg received <8h ago (or timing unknown)]
- Dose: 400 mg IV x1, then 4 mg/min IV up to 480 mg in 120min; Info: for life-threatening or uncontrolled bleeding
- [last apixaban dose >5 mg (or dose unknown) received <8h ago (or timing unknown)]
- Dose: 800 mg IV x1, then 8 mg/min IV up to 960 mg in 120min; Info: for life-threatening or uncontrolled bleeding
- [any apixaban dose received >8h ago]
- Dose: 400 mg IV x1, then 4 mg/min IV up to 480 mg in 120min; Info: for life-threatening or uncontrolled bleeding
rivaroxaban reversal
- [last rivaroxaban dose up to 10 mg received <8h ago (or timing unknown)]
- Dose: 400 mg IV x1, then 4 mg/min IV up to 480 mg in 120min; Info: for life-threatening or uncontrolled bleeding
- [last rivaroxaban dose >10 mg (or dose unknown) received <8h ago (or timing unknown)]
- Dose: 800 mg IV x1, then 8 mg/min IV up to 960 mg in 120min; Info: for life-threatening or uncontrolled bleeding
- [any rivaroxaban dose received >8h ago]
- Dose: 400 mg IV x1, then 4 mg/min IV up to 480 mg in 120min; Max: 480 mg/infusion; Info: for life-threatening or uncontrolled bleeding
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.