Jivi (antihemophilic factor (factor VIII, recombinant), pegylated-aucl)

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = antihemophilic factor (factor VIII, recombinant), pegylated-aucl

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: 10-20 unit/kg/dose IV q24-48h until hemostasis; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%; not 1st line tx

[bleeding episode, moderate]

Dose: 15-30 unit/kg/dose IV q24-48h until hemostasis; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%; not 1st line tx

[bleeding episode, major]

Dose: 30-50 unit/kg/dose IV q8-24h until hemostasis; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%; not 1st line tx

[bleeding prophylaxis, minor surgery]

Dose: 15-30 unit/kg/dose IV q24h for at least 24h until healing achieved; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%; not 1st line tx

[bleeding prophylaxis, major surgery]

Dose: 40-50 unit/kg/dose IV q12-24h until at least 7 days after adequate wound healing; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100% until healing complete, then 30-60% for at least 7 days; not 1st line tx

[routine bleeding prophylaxis]

Dose: 30-40 units/kg/dose IV 2x/wk; Alt: 45-60 units/kg/dose q5 days

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = antihemophilic factor (factor VIII, recombinant), pegylated-aucl

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor, 12 yo and older]

Dose: 10-20 unit/kg/dose IV q24-48h until hemostasis; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%; not 1st line tx

[bleeding episode, moderate, 12 yo and older]

Dose: 15-30 unit/kg/dose IV q24-48h until hemostasis; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%; not 1st line tx

[bleeding episode, major, 12 yo and older]

Dose: 30-50 unit/kg/dose IV q8-24h until hemostasis; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%; not 1st line tx

[bleeding prophylaxis, minor surgery, 12 yo and older]

Dose: 15-30 unit/kg/dose IV q24h for at least 24h until healing achieved; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%; not 1st line tx

[bleeding prophylaxis, major surgery, 12 yo and older]

Dose: 40-50 unit/kg/dose IV q12-24h until at least 7 days after adequate wound healing; Max: 6000 units/dose; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100% until healing complete, then 30-60% for at least 7 days; not 1st line tx

[routine bleeding prophylaxis, 12 yo and older]

Dose: 30-40 units/kg/dose IV 2x/wk; Alt: 45-60 units/kg/dose q5 days

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]