Select a medication above to begin.
Delstrigo
doravirine/ lamivudine/ tenofovir disoproxil
Black Box Warnings .
Hepatitis B Exacerbation
severe acute HBV exacerbations of hepatitis may occur in HBV/HIV co-infected pts when D/C lamivudine or tenofovir; monitor hepatic fxn closely for at least several months in HBV/HIV co-infected pts who D/C doravirine/lamivudine/tenofovir; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 100 mg/300 mg/300 mg
HIV infection
- [1 tab PO qd]
renal dosing
- [see below]
- CrCl <50: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: TAB: 100 mg/300 mg/300 mg
HIV infection
- [>35 kg]
- Dose: 1 tab PO qd
renal dosing
- [see below]
- CrCl <50: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined