Revcovi (elapegademase-lvlr)

Adult Dosing .

Dosage forms:  INJ: 2.4 mg per 1.5 mL

Special Note

[drug name clarification]

Info: nonproprietary name = elapegademase-lvlr

adenosine deaminase severe combined immune deficiency

[pegademase bovine tx-naive patients]

Dose: individualize dose IM divided 2x/wk; Start: 0.4 mg/kg/dose IM divided 2x/wk for at least 12-24wk until immune reconstitution is achieved; Info: use actual body wt or ideal body wt, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

[conversion from pegademase bovine, dose unknown or <30 units/kg/wk]

Dose: individualize dose IM divided by the desired number of doses per wk; Start: 0.2 mg/kg/dose IM qwk, then may incr. dose by 0.033 mg/kg/wk; Info: use actual body wt or ideal body wt, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

[conversion from pegademase bovine, dose >30 units/kg/wk]

Dose: individualize dose IM divided by the desired number of doses per wk; Start: weekly IM dose (mg/kg/dose) = [last pegademase bovine dose (units/kg)] divided by 150, then may incr. dose by 0.033 mg/kg/wk; Info: use actual body wt or ideal body wt, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 2.4 mg per 1.5 mL

Special Note

[drug name clarification]

Info: nonproprietary name = elapegademase-lvlr

adenosine deaminase severe combined immune deficiency

[pegademase bovine tx-naive patients]

Dose: individualize dose IM divided 2x/wk; Start: 0.4 mg/kg/dose IM divided 2x/wk for at least 12-24wk until immune reconstitution is achieved; Info: use actual body wt or ideal body wt, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

[conversion from pegademase bovine, dose unknown or <30 units/kg/wk]

Dose: individualize dose IM divided by the desired number of doses per wk; Start: 0.2 mg/kg/dose IM qwk, then may incr. dose by 0.033 mg/kg/wk; Info: use actual body wt or ideal body wt, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

[conversion from pegademase bovine, dose >30 units/kg/wk]

Dose: individualize dose IM divided by the desired number of doses per wk; Start: weekly IM dose (mg/kg/dose) = [last pegademase bovine dose (units/kg)] divided by 150, then may incr. dose by 0.033 mg/kg/wk; Info: use actual body wt or ideal body wt, whichever is greater; adjust dose based on plasma ADA activity, rbc dAXP levels, and immune reconstitution

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]