Firdapse

Adult Dosing .

Dosage forms:  TAB: 10 mg

Restricted Distribution in US

[1-833-422-8259 or www.yourcatalystpathways.com for more info]

Lambert-Eaton myasthenic syndrome

[15-100 mg/day PO divided 3-5x/day]

Start: 15-30 mg/day PO divided 3-5x/day, may incr. by 5 mg/day q3-4 days; Max: 20 mg/dose, 100 mg/day; Info: start 15 mg/day PO divided 3-5x/day in N-acetyltransferase 2 (NAT2) poor metabolizers; see pkg insert for suspension preparation

renal dosing

[adjust dose amount]

CrCl 15-90: start 15 mg/day divided 3-5x/day; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: start 15 mg/day divided 3-5x/day

Peds Dosing .

Dosage forms:  TAB: 10 mg

Restricted Distribution in US

[1-833-422-8259 or www.yourcatalystpathways.com for more info]

Lambert-Eaton myasthenic syndrome

[6 yo and older, <45 kg]

Dose: 5-50 mg/day PO divided 3-5x/day; Start 5-15 mg/day PO divided 3-5x/day, may incr. by 2.5 mg/day q3-4 days; Max: 10 mg/dose, 50 mg/day; Info: start 5 mg/day PO divided 3-5x/day in N-acetyltransferase 2 (NAT2) poor metabolizers; see pkg insert for suspension preparation

[6 yo and older, >45 kg]

Dose: 15-100 mg/day PO divided 3-5x/day; Start: 15-30 mg/day PO divided 3-5x/day, may incr. by 5 mg/day q3-4 days; Max: 20 mg/dose, 100 mg/day; Info: start 15 mg/day PO divided 3-5x/day in N-acetyltransferase 2 (NAT2) poor metabolizers; see pkg insert for suspension preparation

renal dosing

[6 yo and older, <45 kg]

CrCl 15-90: start 5 mg/day divided 3-5x/day; CrCl <15: not defined

HD/PD: not defined

[6 yo and older, >45 kg]

CrCl 15-90: start 15 mg/day divided 3-5x/day; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[6 yo and older, <45 kg]

hepatic impairment: start 5 mg/day divided 3-5x/day

[6 yo and older, >45 kg]

hepatic impairment: start 15 mg/day divided 3-5x/day