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Inrebic
fedratinib
Black Box Warnings .
Encephalopathy
serious and fatal cases have occurred, incl. Wernicke, a neurologic emergency; assess thiamine levels, nutritional status at baseline, periodically during tx, and as clinically indicated; do not start tx if thiamine deficiency; replete thiamine before tx start, give PO thiamine qd during tx; D/C tx, give parenteral thiamine immed. if encephalopathy suspected; monitor until symptoms resolve or improve and thiamine levels normalize
Adult Dosing .
Dosage forms: CAP: 100 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, concomitant meds, and dosing incl. toxicity-related dose adjustments
myelofibrosis, intermediate-2 or high-risk
- [400 mg PO qd]
- Info: for patients w/ baseline Plt 50,000 or greater w/ primary or secondary dz
renal dosing
- [adjust dose amount]
- CrCl 15-29: 200 mg qd; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.