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Xembify (immune globulin human-klhw)
immune globulin (human)
Black Box Warnings .
Thrombosis
may occur w/ immune globulin products; risk factors incl. advanced age, prolonged immobilization, hypercoagulable conditions, venous or arterial thrombosis hx, estrogen use, indwelling central vascular catheter, hyperviscosity, and cardiovascular dz risk; thrombosis may occur in pts w/o risk factors; use minimum dose and infusion rate practicable in pts at risk; ensure adequate hydration before admin; monitor for s/sx thrombosis and assess blood viscosity in pts w/ hyperviscosity risk
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = immune globulin human-klhw
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing
primary immunodeficiency
- [tx-experienced pts, frequent dosing (2-7x/wk)]
- Dose: frequent SCIG dose = [last IVIG dose (g) x 1.37] divided by last IVIG dosing interval (wk) divided by the desired number of doses per wk; Start: 1wk after receiving last IVIG or SCIG dose; Alt: divide last weekly SCIG dose by the desired number of doses per wk; Info: adjust dose based on trough IgG levels and clinical response
- [tx-experienced pts, weekly dosing]
- Dose: weekly SCIG dose = [last IVIG dose (g) x 1.37] divided by last IVIG dosing interval (wk); Start: 1wk after receiving last IVIG or SCIG dose; Alt: maintain previous weekly SCIG dose; Info: adjust dose based on trough IgG levels and clinical response
- [tx-experienced pts, biweekly dosing (q2wk)]
- Dose: weekly SCIG dose = [last IVIG dose (g) x 1.37] divided by last IVIG dosing interval (wk) x2; Start: 1wk after receiving last IVIG or SCIG dose; Alt: maintain previous weekly SCIG dose x2; Info: adjust dose based on trough IgG levels and clinical response
- [tx-naive pts]
- Dose: 150 mg/kg/dose SC qwk on day 8; Start: 150 mg/kg/dose SC qd x5 consecutive days; Info: adjust dose based on trough IgG levels and clinical response
renal dosing
- [see below]
- renal impairment: not defined, consider lower, more frequent dosing
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = immune globulin human-klhw
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing
primary immunodeficiency
- [tx-experienced pts, frequent dosing (2-7x/wk), 2 yo and older]
- Dose: frequent SCIG dose = [last IVIG dose (g) x 1.37] divided by last IVIG dosing interval (wk) divided by the desired number of doses per wk; Start: 1wk after receiving last IVIG or SCIG dose; Alt: divide last weekly SCIG dose by the desired number of doses per wk; Info: adjust dose based on trough IgG levels and clinical response
- [tx-experienced pts, weekly dosing, 2 yo and older]
- Dose: weekly SCIG dose = [last IVIG dose (g) x 1.37] divided by last IVIG dosing interval (wk); Start: 1wk after receiving last IVIG or SCIG dose; Alt: maintain previous weekly SCIG dose; Info: adjust dose based on trough IgG levels and clinical response
- [tx-experienced pts, biweekly dosing (q2wk), 2 yo and older]
- Dose: weekly SCIG dose = [last IVIG dose (g) x 1.37] divided by last IVIG dosing interval (wk) x2; Start: 1wk after receiving last IVIG or SCIG dose; Alt: maintain previous weekly SCIG dose x2; Info: adjust dose based on trough IgG levels and clinical response
- [tx-naive pts, 2 yo and older]
- Dose: 150 mg/kg/dose SC qwk on day 8; Start: 150 mg/kg/dose SC qd x5 consecutive days; Info: adjust dose based on trough IgG levels and clinical response
renal dosing
- [see below]
- renal impairment: not defined, consider lower, more frequent dosing
- HD/PD: not defined
hepatic dosing
- [not defined]