Zeposia

Adult Dosing .

Dosage forms:  CAP: 0.92 mg; CAP (7-day starter pack): 0.23 mg x4 and 0.46 mg x3; CAP (28-day starter pack): 0.23 mg x4, 0.46 mg x3, and 0.92 mg x21

multiple sclerosis, relapsing forms

[0.92 mg PO qd]

Start: 0.23 mg PO qd x4 days, then 0.46 mg PO qd x3 days, then 0.92 mg PO qd; Info: for patients w/ clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease; restart titration if dose missed w/in first 2wk of tx

ulcerative colitis, moderate-severe

[0.92 mg PO qd]

Start: 0.23 mg PO qd x4 days, then 0.46 mg PO qd x3 days, then 0.92 mg PO qd; Info: restart titration if dose missed w/in first 2wk of tx

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: 0.23 mg qd x4 days, then 0.46 mg qd x3 days, then 0.92 mg qod; Child-Pugh Class C: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.