Veklury

Adult Dosing .

Dosage forms:  INJ

COVID-19

[mild-moderate]

Dose: 200 mg IV x1, then 100 mg IV q24h x2 days; Start: ASAP within 7 days of symptom onset; Info: for non-hospitalized patients at high risk for disease progression

[severe]

Dose: 200 mg IV x1, then 100 mg IV q24h x4 days; Info: for hospitalized patients >40 kg not requiring mechanical ventilation and/or ECMO; may give with baricitinib per baricitinib FDA Emergency Use Authorization; ECMO = extracorporeal membrane oxygenation

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

COVID-19, mild-moderate

[0-27 days old, >1.5 kg]

Dose: 2.5 mg/kg/dose IV x1, then 1.25 mg/kg/dose IV q24h x2 days; Start: ASAP within 7 days of symptom onset; Info: for non-hospitalized patients at high risk for disease progression; use IV powder form due to lower IV vehicle amount

[28 days old and older, 1.5-2.9 kg]

Dose: 2.5 mg/kg/dose IV x1, then 1.25 mg/kg/dose IV q24h x2 days; Start: ASAP within 7 days of symptom onset; Info: for non-hospitalized patients at high risk for disease progression; use IV powder form due to lower IV vehicle amount

[28 days old and older, 3-39 kg]

Dose: 5 mg/kg/dose IV x1, then 2.5 mg/kg/dose IV q24h x2 days; Start: ASAP within 7 days of symptom onset; Info: for non-hospitalized patients at high risk for disease progression; use IV powder form due to lower IV vehicle amount

[28 days old and older, >40 kg]

Dose: 200 mg IV x1, then 100 mg IV q24h x2 days; Start: ASAP within 7 days of symptom onset; Info: for non-hospitalized patients at high risk for disease progression

COVID-19, severe

[0-27 days old, >1.5 kg]

Dose: 2.5 mg/kg/dose IV x1, then 1.25 mg/kg/dose IV q24h x4 days; Info: for hospitalized patients >40 kg not requiring mechanical ventilation and/or ECMO; may extend tx for up to 5 additional days if no clinical improvement; use IV powder form due to lower IV vehicle amount; ECMO = extracorporeal membrane oxygenation

[28 days old and older, 1.5-2.9 kg]

Dose: 2.5 mg/kg/dose IV x1, then 1.25 mg/kg/dose IV q24h x4 days; Info: for hospitalized patients >40 kg not requiring mechanical ventilation and/or ECMO; may give with baricitinib per baricitinib FDA EUA in patients 2 yo and older; may extend tx for up to 5 additional days if no clinical improvement; use IV powder form due to lower IV vehicle amount; ECMO = extracorporeal membrane oxygenation

[28 days old and older, 3-39 kg]

Dose: 5 mg/kg/dose IV x1, then 2.5 mg/kg/dose IV q24h x4 days; Info: for hospitalized patients >40 kg not requiring mechanical ventilation and/or ECMO; may give with baricitinib per baricitinib FDA EUA in patients 2 yo and older; may extend tx for up to 5 additional days if no clinical improvement; use IV powder form due to lower IV vehicle amount; ECMO = extracorporeal membrane oxygenation

[28 days old and older, >40 kg]

Dose: 200 mg IV x1, then 100 mg IV q24h x4 days; Info: for hospitalized patients >40 kg not requiring mechanical ventilation and/or ECMO; may give with baricitinib per baricitinib FDA EUA in patients 2 yo and older; may extend tx for up to 5 additional days if no clinical improvement; ECMO = extracorporeal membrane oxygenation

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[no adjustment]