Lyumjev (insulin lispro-aabc)

Adult Dosing .

Dosage forms:  INJ (U-100 cartridge): 100 units per mL; INJ (KwikPen U-100 pen, Junior KwikPen U-100 pen, Tempo U-100 pen): 100 units per mL; INJ (U-100 vial): 100 units per mL; INJ (KwikPen U-200 pen): 200 units per mL

Dosage Form Details

[formulation clarification]

Info: 200 units per mL (U-200) strength for intermittent SC injection use only; contains citrate (inactive ingredient) and treprostinil (microdose) for faster onset and absorption

Special Note

[drug name clarification]

Info: nonproprietary name = insulin lispro-aabc

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[intermittent SC injection]

Dose: individualize dose SC bid-qid; Start: 50-60% x (0.4-0.5 units/kg/day) SC in divided doses, may adjust dose by 1-4 units or 5-10% 1-2x/wk; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); give at start of meal or within 20min after starting meal; use with intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immediately postpartum; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

[continuous SC infusion]

Dose: individualize dose (100 units per mL) via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); dose adjustment may be needed during pregnancy and/or immediately postpartum; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

[IV route]

Dose: individualize dose (100 units per mL) via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immediately postpartum

diabetes mellitus, type 2

[intermittent SC injection]

Dose: individualize dose SC bid-qid; Start: 4 units SC qd or 10% of basal insulin dose SC qd, may incr. dose by 1-2 units or 10-15% 2x/wk; Info: give at start of meal or within 20min after starting meal; use with intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immediately postpartum; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

[continuous SC infusion]

Dose: individualize dose (100 units per mL) via continuous SC infusion pump; Info: dose adjustment may be needed during pregnancy and/or immediately postpartum; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

[IV route]

Dose: individualize dose (100 units per mL) via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immediately postpartum

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ (U-100 cartridge): 100 units per mL; INJ (Junior KwikPen U-100 pen, KwikPen U-100 pen, Tempo U-100 pen): 100 units per mL; INJ (U-100 vial): 100 units per mL; INJ (KwikPen U-200 pen): 200 units per mL

Dosage Form Details

[formulation clarification]

Info: 200 units per mL (U-200) strength for intermittent SC injection use only; contains citrate (inactive ingredient) and treprostinil (microdose) for faster onset and absorption

Special Note

[drug name clarification]

Info: nonproprietary name = insulin lispro-aabc

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[intermittent SC injection, 1 yo and older]

Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; give at start of meal or within 20min after starting meal; use with intermediate-acting or long-acting insulin; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

[continuous SC infusion, 1 yo and older]

Dose: individualize dose (100 units per mL) via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

diabetes mellitus, type 2

[intermittent SC injection]

Dose: individualize dose SC bid-qid; Info: give at start of meal or within 20min after starting meal; use with intermediate-acting or long-acting insulin; onset 1min, peak 57min, duration <5h (rapid-acting insulin)

[continuous SC infusion]

Dose: individualize dose (100 units per mL) via continuous SC infusion pump; Info: onset 1min, peak 57min, duration <5h (rapid-acting insulin)

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised