Oxlumo

Adult Dosing .

Dosage forms:  INJ: 94.5 mg per 0.5 mL

primary hyperoxaluria, type 1

[3 mg/kg/dose SC q3mo]

Start: 3 mg/kg/dose SC qmo x3; Max: 1.5 mL/injection site

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment, on dialysis days administer after dialysis; supplement not defined; PD: not defined

hepatic dosing

[see below]

bilirubin 1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN: not defined

Peds Dosing .

Dosage forms:  INJ: 94.5 mg per 0.5 mL

primary hyperoxaluria, type 1

[<10 kg]

Dose: 3 mg/kg/dose SC qmo; Start: 6 mg/kg/dose SC qmo x3; Max: 1.5 mL/injection site

[10-19 kg]

Dose: 6 mg/kg/dose SC q3mo; Start: 6 mg/kg/dose SC qmo x3; Max: 1.5 mL/injection site

[>20 kg]

Dose: 3 mg/kg/dose SC q3mo; Start: 3 mg/kg/dose SC qmo x3; Max: 1.5 mL/injection site

renal dosing

[see below]

renal impairment: no adjustment

HD: no adjustment, on dialysis days administer after dialysis; supplement not defined; PD: not defined

hepatic dosing

[see below]

bilirubin 1-3x ULN or AST >ULN: no adjustment; bilirubin >3x ULN: not defined