NAG

Reported Uses

• NOTE: see Herb & Supplement Effectiveness Rating Definitions table
• arthralgia, aromatase inhibitor-induced [Insufficient Evidence]
• back pain [Insufficient Evidence]
• cancer [Insufficient Evidence]
• cardiovascular dz prevention [Insufficient Evidence]
• colorectal adenoma [Insufficient Evidence]
• colorectal CA [Insufficient Evidence]
• COVID-19 [Insufficient Evidence]
• dementia [Insufficient Evidence]
• depression [Insufficient Evidence]
• diabetes mellitus, type 2 [Insufficient Evidence]
• gout [Insufficient Evidence]
• heart failure [Insufficient Evidence]
• hyperlipidemia [Insufficient Evidence]
• inflammatory bowel dz [Insufficient Evidence]
• interstitial cystitis [Insufficient Evidence]
• joint pain [Insufficient Evidence]
• Kashin-Beck dz [Insufficient Evidence]
• knee pain [Insufficient Evidence]
• multiple sclerosis [Insufficient Evidence]
• nephrolithiasis [Insufficient Evidence]
• osteoarthritis [Likely Effective]
• overall mortality [Insufficient Evidence]
• postop recovery [Insufficient Evidence]
• rheumatoid arthritis [Insufficient Evidence]
• skin aging [Insufficient Evidence]
• stroke prevention [Insufficient Evidence]
• temporomandibular disorder [Insufficient Evidence]
• wound healing [Insufficient Evidence]

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

arthralgia, aromatase inhibitor-induced

[Insufficient Evidence]

Dose: 1500 mg/day glucosamine sulfate PO divided bid-tid; Info: used w/ chondroitin sulfate

depression

[Insufficient Evidence]

Dose: 2 g glucosamine hydrochloride PO qd; Start: 1 g PO qd x1wk

inflammatory bowel dz, peds pts

[Insufficient Evidence]

Dose: 1.5-2 g N-acetyl glucosamine PO bid; Alt: 1.5-2 g N-acetyl glucosamine rectally bid; Info: prepared w/ 10 mL water; for pts 8-17 yo

interstitial cystitis

[Insufficient Evidence]

Dose: 240 mg glucosamine sulfate PO bid; Info: used w/ chondroitin sulfate

joint pain

[Insufficient Evidence]

Dose: 500 mg glucosamine sulfate PO tid

Kashin-Beck dz

[Insufficient Evidence]

Dose: 480 mg glucosamine hydrochloride PO tid; Alt: 750 mg glucosamine hydrochloride PO bid; Info: used w/ or w/o chondroitin sulfate

knee pain

[Insufficient Evidence]

Dose: 500 mg glucosamine sulfate PO tid; Alt: 2000 mg glucosamine hydrochloride PO qd

multiple sclerosis

[Insufficient Evidence]

Dose: 1000 mg glucosamine sulfate PO qd

osteoarthritis

[Likely Effective]

Dose: 1500 mg/day glucosamine sulfate PO divided qd-tid; Alt: 480 mg glucosamine hydrochloride PO q12h; 500 mg glucosamine hydrochloride PO tid x3wk, then 500 mg PO bid; 1200-2000 mg/day glucosamine hydrochloride PO divided qd-tid; Info: commonly used w/ chondroitin sulfate

rheumatoid arthritis

[Insufficient Evidence]

Dose: 500 mg glucosamine hydrochloride PO tid

skin aging

[Insufficient Evidence]

Dose: apply 2% N-acetyl glucosamine cream topically to face bid; Info: used w/ niacinamide

temporomandibular disorder

[Insufficient Evidence]

Dose: 1500 mg/day glucosamine sulfate PO divided qd-tid