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herbe aux fées
St. John's wort (Hypericum perforatum)
Entire Monograph
Reported Uses
- NOTE: see Herb & Supplement Effectiveness Rating Definitions table
- acne [Insufficient Evidence]
- ADHD [Insufficient Evidence]
- anxiety [Insufficient Evidence]
- brain tumor [Insufficient Evidence]
- burning mouth syndrome [Possibly Ineffective]
- chronic fatigue syndrome [Insufficient Evidence]
- Crigler-Najjar syndrome type 2 [Insufficient Evidence]
- depression [Likely Effective]
- fibromyalgia [Insufficient Evidence]
- genital herpes [Insufficient Evidence]
- hepatitis C [Possibly Ineffective]
- herpes labialis (cold sores) [Insufficient Evidence]
- HIV/AIDS [Possibly Ineffective]
- IBS [Possibly Ineffective]
- mastitis [Insufficient Evidence]
- memory [Insufficient Evidence]
- menopausal sx [Possibly Effective]
- migraine prophylaxis [Insufficient Evidence]
- obsessive-compulsive disorder [Insufficient Evidence]
- osteoarthritis [Insufficient Evidence]
- peripheral neuropathy [Possibly Ineffective]
- plaque psoriasis [Insufficient Evidence]
- polycystic ovary syndrome [Insufficient Evidence]
- premenstrual syndrome [Insufficient Evidence]
- scleroderma [Insufficient Evidence]
- seasonal affective disorder [Insufficient Evidence]
- smoking cessation [Insufficient Evidence]
- social anxiety disorder [Possibly Ineffective]
- somatoform disorders [Possibly Effective]
- tinnitus [Insufficient Evidence]
- wound healing [Insufficient Evidence]
Reported Doses
Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely
Special Note
- [formulation clarification]
- Info: products generally stdzd to contain hypericin 0.1-0.3% and/or hyperforin 0.5-6%
Effectiveness Ratings
- [see Herb & Supplement Effectiveness Rating Definitions table]
acne
- [Insufficient Evidence]
- Dose: apply 1.5 mL (0.5% extract) topically x10min
brain tumor
- [Insufficient Evidence]
- Dose: 0.05-0.5 mg/kg/dose hypericin extract PO qd
Crigler-Najjar syndrome type 2
- [Insufficient Evidence]
- Dose: 300 mg PO tid
depression, adult pts
- [Likely Effective]
- Dose: 600-1800 mg/day PO divided qd-tid (stdzd to 0.2-0.3 % hypericin and 5-6% hyperforin); Alt: 300 mg PO tid (stdzd to 0.3% hypericin); 250 mg PO bid (stdzd to 0.2% hypericin); 300-600 mg PO tid (stdzd to 3-6% hyperforin)
depression, peds pts
- [Likely Effective]
- Dose: 150-300 mg PO tid in pts 6-17 yo; Alt: 100-600 mg PO tid (stdzd to 0.3% hypericin) in pts 12 yo and younger
genital herpes
- [Insufficient Evidence]
- Dose: apply 0.1% liquid topically x1
herpes labialis (cold sores)
- [Insufficient Evidence]
- Dose: apply 0.1% liquid topically x1
mastitis
- [Insufficient Evidence]
- Dose: apply oil topically x2min bid
memory
- [Insufficient Evidence]
- Dose: 250 mg PO x1 (stdzd to 0.5 mg hypericin)
menopausal sx
- [Possibly Effective]
- Dose: 900 mg/day PO divided qd-tid; Alt: 0.2 mg/mL hypericin extract PO tid; 0.25 mg hypericin extract PO qd-bid
migraine prophylaxis
- [Insufficient Evidence]
- Dose: 160 mg PO tid; Info: used w/ valproate
obsessive-compulsive disorder
- [Insufficient Evidence]
- Dose: 450 mg PO bid (stdzd to 0.3% hypericin)
osteoarthritis
- [Insufficient Evidence]
- Dose: apply oil topically tid; Info: used w/ or w/o analgesics
plaque psoriasis
- [Insufficient Evidence]
- Dose: apply 5% ointment topically bid
polycystic ovary syndrome
- [Insufficient Evidence]
- Dose: 2250 mg PO qd
premenstrual syndrome
- [Insufficient Evidence]
- Dose: 1.36 mg hypericin extract PO qd; Alt: 450 mg PO bid (stdzd to 0.18% hypericin and 3.38% hyperforin)
scleroderma
- [Insufficient Evidence]
- Dose: apply cream topically qd
seasonal affective disorder
- [Insufficient Evidence]
- Dose: 900 mg/day PO divided qd-tid
somatoform disorders
- [Possibly Effective]
- Dose: 300 mg PO bid
wound healing
- [Insufficient Evidence]
- Dose: apply 20% ointment topically tid; Start: 24h after cesarean section
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