genistein (soy)

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies with variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Special Note

[formulation clarification]

Info: may include whole soy foods, isolated soy protein, soy fiber or soy extracts; soy products contain isoflavone phytoestrogens, such as genistein and daidzein

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

asthma

[Insufficient Evidence]

Dose: 250 mcg genistein PO for every 1000 kcal consumed

cognitive function

[Insufficient Evidence]

Dose: 60-110 mg soy isoflavones PO qd

diabetes mellitus

[Possibly Effective]

Dose: 300 mg Touchi extract PO tid; Alt: 40-161 mg soy isoflavones PO qd; 0.3 g/kg/day soy protein PO in divided doses starting 24-28 wk gestation

diarrhea, peds patients

[Possibly Effective]

Dose: soy fiber-fortified formula PO 3-8x/day; Info: individualize dose; soy protein content 1.8-2 g/dL of soy formula

hepatitis C

[Insufficient Evidence]

Dose: 32 g soy protein PO qd

HTN

[Possibly Effective]

Dose: 18-40 g soy protein PO qd; Alt: 4.5 g black soy peptide PO qd

hyperlipidemia

[Possibly Effective]

Dose: 20-50 g soy protein PO qd

IBS

[Insufficient Evidence]

Dose: 40 mg soy isoflavones PO qd

CKD

[Possibly Effective]

Dose: 700-800 mg/kg/day soy protein PO in divided doses; Max: 800 mg/kg/day

mastalgia

[Insufficient Evidence]

Dose: 17 g soy milk PO bid

menopausal symptoms

[Possibly Effective]

Dose: 34-200 mg/day soy isoflavones PO divided qd-tid

menstrual migraine prophylaxis

[Insufficient Evidence]

Dose: 60 mg soy isoflavones PO qd; Info: used with dong quai and black cohosh

metabolic syndrome

[Possibly Effective]

Dose: 30 g soy nut or soy protein PO qd; Info: dietary replacement of red meat

muscle strength

[Possibly Effective]

Dose: 1.2-1.5 g/kg/day soy protein PO in divided doses; Alt: 25 g soy protein PO qd

neonatal jaundice prevention

[Insufficient Evidence]

Dose: 0.3 g/kg/day soy protein PO in divided doses; Start: 24-28 wk gestation

obesity

[Insufficient Evidence]

Dose: 4.5 g black soy peptide PO qd; Alt: 100 g soy fiber PO qd; 52 g soy protein PO bid

osteoarthritis

[Insufficient Evidence]

Dose: 40 g soy protein PO qd

osteoporosis

[Possibly Effective]

Dose: 50-90 mg soy isoflavones PO qd

overall mortality

[Insufficient Evidence]

Dose: 60 g soy PO qd

polycystic ovary syndrome

[Insufficient Evidence]

Dose: 50 mg soy isoflavones PO qd

premenstrual syndrome

[Insufficient Evidence]

Dose: 68 mg soy isoflavones PO qd

prostate CA, tx or prevention

[Insufficient Evidence]

Dose: 8 oz soy milk PO tid; Alt: 107-117 mg soy isoflavones PO qd

sarcopenia

[Insufficient Evidence]

Dose: 16 g soy protein PO qd

vaginal atrophy

[Insufficient Evidence]

Dose: 1 g PV qd; Info: 4% isoflavone vaginal gel

wrinkled skin

[Insufficient Evidence]

Dose: 40 mg soy isoflavones PO qd; Alt: apply soy based moisturizer topically bid