L-5-Hydroxytryptophan

Reported Uses

• NOTE: see Herb & Supplement Effectiveness Rating Definitions table
• ADHD [Insufficient Evidence]
• alcohol withdrawal sx [Insufficient Evidence]
• Alzheimer dementia [Insufficient Evidence]
• anxiety [Insufficient Evidence]
• cerebellar ataxia [Insufficient Evidence]
• depression [Possibly Effective]
• Down syndrome [Possibly Ineffective]
• fibromyalgia [Insufficient Evidence]
• menopausal sx [Insufficient Evidence]
• migraine prophylaxis [Insufficient Evidence]
• obesity [Insufficient Evidence]
• obsessive-compulsive disorder [Insufficient Evidence]
• opioid withdrawal sx [Insufficient Evidence]
• panic disorder [Insufficient Evidence]
• Parkinson dz [Insufficient Evidence]
• premenstrual syndrome [Insufficient Evidence]
• seizures [Insufficient Evidence]
• tension headache [Insufficient Evidence]
• tinnitus [Insufficient Evidence]

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

alcohol withdrawal sx

[Insufficient Evidence]

Dose: 5 mg PO qd

anxiety

[Insufficient Evidence]

Dose: 25-150 mg PO qd; Info: used w/ peripheral decarboxylase inhibitor

cerebellar ataxia

[Insufficient Evidence]

Dose: 10 mg/kg/dose PO qd

depression

[Possibly Effective]

Dose: 150-800 mg PO qd; Info: up to 3000 mg/day has been used

fibromyalgia

[Insufficient Evidence]

Dose: 100 mg PO tid

migraine prophylaxis

[Insufficient Evidence]

Dose: 600 mg PO qd

obesity

[Insufficient Evidence]

Dose: 250-300 mg PO tid; Info: give 30min before meals

obsessive-compulsive disorder

[Insufficient Evidence]

Dose: 200 mg PO qd; Info: used w/ selective serotonin reuptake inhibitor

opioid withdrawal sx

[Insufficient Evidence]

Dose: 200 mg PO qd

Parkinson dz

[Insufficient Evidence]

Dose: 50 mg PO qd; Info: used w/ peripheral decarboxylase inhibitor