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Kirsty (insulin aspart-xjhz)
insulin aspart
Adult Dosing .
Dosage forms: INJ (U-100 pen): 100 units per mL; INJ (U-100 vial): 100 units per mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = insulin aspart-xjhz
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [intermittent SC injection]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); give 5-10min before meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion]
- Dose: individualize dose via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum
diabetes mellitus, type 2
- [intermittent SC injection]
- Dose: individualize dose SC bid-qid; Start: 4 units SC qd or 10% of basal insulin dose SC qd, may incr. dose by 1-2 units or 10-15% 2x/wk; Info: give 5-10min before meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion]
- Dose: individualize dose via continuous SC infusion pump; Info: dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum
diabetic ketoacidosis, mild-moderate uncomplicated (off-label)
- [q1h dosing regimen]
- Dose: 0.1 units/kg/dose SC q1h; Start: 0.1 units/kg/dose SC x1; Info: when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/dose SC q1h and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; refer to institutional protocol
- [q2h dosing regimen]
- Dose: 0.2 units/kg/dose SC q2h; Start: 0.1 units/kg/dose SC x1; Info: when blood glucose <250 mg/dL, decr. dose to 0.1 units/kg/dose SC q2h and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; refer to institutional protocol
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ (U-100 pen): 100 units per mL; INJ (U-100 vial): 100 units per mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = insulin aspart-xjhz
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [intermittent SC injection, 2 yo and older]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; give 5-10min before meals; use w/ intermediate-acting or long-acting insulin; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion, 2 yo and older]
- Dose: individualize dose via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
diabetes mellitus, type 2
- [intermittent SC injection]
- Dose: individualize dose SC bid-qid; Info: give 5-10min before meals; use w/ intermediate-acting or long-acting insulin; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion]
- Dose: individualize dose via continuous SC infusion pump; Info: onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
diabetic ketoacidosis, mild-moderate uncomplicated (off-label)
- [0.15 units/kg/dose SC q2h]
- Start: 1h after initial fluid tx; Info: add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; may decr. dose to 0.1 units/kg/dose SC q2h if blood glucose continues to decr. by >90 mg/dL/h; maintain blood glucose at 200 mg/dL until DKA resolves; refer to institutional protocol
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypoglycemia
- caution: hypoglycemia unawareness
- caution: illness
- caution: stress
- caution: hypokalemia risk
- caution: renal impairment
- caution: hepatic impairment
- caution: visual impairment (pen form)
- caution: localized cutaneous amyloidosis
- caution: lipodystrophy
Drug Interactions .
Overview
insulin
insulin
- affects growth hormone diagnostic test results
- antidiabetic agent
- hypokalemia
zinc (inactive ingredient)
heavy metal
- heavy metal
Avoid/Use Alternative
- arsenic trioxide
- macimorelin
- repaglinide
- rosiglitazone
Monitor/Modify Tx
- abiraterone acetate
- acarbose
- acebutolol
- acetazolamide
- albuterol
- albuterol inhaled
- alclometasone topical
- aloe
- alogliptin
- alpelisib
- amcinonide topical
- amphotericin
- arformoterol inhaled
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- asenapine
- ashwagandha
- asparaginase
- aspirin
- atazanavir
- azilsartan medoxomil
- benazepril
- berberine
- betamethasone
- betamethasone topical
- bexagliflozin
- bexarotene
- bismuth subsalicylate
- bortezomib
- brentuximab vedotin
- brexpiprazole
- brigatinib
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- ceritinib
- cetuximab
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- chromium
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- dienogest (contraceptive)
- diflorasone topical
- digoxin
- dinutuximab
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- dulaglutide
- edetate calcium disodium
- eleuthero
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- enfortumab vedotin
- ensartinib
- ephedra
- epinephrine
- ertugliflozin
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethacrynic acid
- ethanol
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethionamide
- ethynodiol (contraceptive)
- etonogestrel (contraceptive)
- everolimus
- exenatide
- fenofibrate
- fenofibric acid
- fenugreek
- flaxseed
- fludrocortisone
- fluocinolone otic
- fluocinolone topical
- fluocinonide topical
- fluoxetine
- flurandrenolide topical
- fluticasone propionate topical
- formoterol inhaled
- fosamprenavir
- foscarnet
- fosphenytoin
- furosemide
- garlic
- gemfibrozil
- ginkgo
- ginseng, American
- ginseng, Asian
- glimepiride
- glipizide
- glucagon
- glyburide
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- gymnema
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- hydrocortisone topical
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- iloperidone
- inavolisib
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- levalbuterol inhaled
- levofloxacin
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- levothyroxine
- licorice
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- linezolid
- liothyronine
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- lithium
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- losartan
- lumateperone
- lurasidone
- lutetium Lu 177 dotatate
- magnesium citrate
- magnesium salicylate
- mannitol
- mecasermin
- medroxyprogesterone (contraceptive)
- megestrol
- metformin
- methazolamide
- methylprednisolone
- methyltestosterone
- metoclopramide
- metolazone
- metreleptin
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- miglitol
- milk thistle
- mometasone topical
- motixafortide
- moxifloxacin
- nadolol
- nateglinide
- necitumumab
- nelfinavir
- niacin (vitamin B3)
- nilotinib
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- norepinephrine
- norethindrone (contraceptive)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- octreotide
- ofloxacin
- olanzapine
- olmesartan medoxomil
- olodaterol inhaled
- osilodrostat
- paliperidone
- pamidronate
- panitumumab
- pasireotide
- pegaspargase
- peginterferon alfa 2a
- pegvisomant
- pentamidine
- pentoxifylline
- phenelzine
- phenylephrine
- phenytoin
- pindolol
- pioglitazone
- polyethylene glycol
- polyethylene glycol/electrolytes
- posaconazole
- pramlintide
- prednicarbate topical
- prednisolone
- prednisone
- pseudoephedrine
- quetiapine
- quinine
- ribose
- risperidone
- ritonavir
- sacituzumab govitecan
- sacrosidase
- salmeterol inhaled
- salsalate
- saxagliptin
- segesterone (contraceptive)
- selinexor
- semaglutide
- sirolimus albumin-bound
- sitagliptin
- sodium benzoate
- sodium phenylacetate
- sodium phenylbutyrate
- sodium polystyrene sulfonate
- sodium thiosulfate
- somapacitan
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- spironolactone
- sucralfate
- sulfadiazine
- sulfamethoxazole
- sulfasalazine
- sulfate bowel prep
- sunitinib
- tafasitamab
- telmisartan
- temsirolimus
- teprotumumab
- terbutaline
- tesamorelin
- testosterone
- thyroid
- timolol
- tipranavir
- tirzepatide
- topiramate
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trastuzumab
- triamcinolone
- triamcinolone topical
- triamterene
- triptorelin
- turmeric
- valsartan
- vamorolone
- vilanterol inhaled
- vorinostat
- ziprasidone
- zonisamide
Adverse Reactions .
Serious Reactions
- hypoglycemia
- hypokalemia
- hypersensitivity rxn
- anaphylaxis
Common Reactions
- hypoglycemia
- headache
- hyporeflexia
- onychomycosis
- sensory disturbance
- UTI
- nausea
- diarrhea
- chest pain
- pruritus
- rash
- abdominal pain
- URI
- weight gain
- edema, peripheral
- injection site rxn
- injection site lipodystrophy
- localized cutaneous amyloidosis
Safety/Monitoring .
Monitoring Parameters
Cr at baseline; K if hypokalemia risk
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; drug of choice for diabetes use during pregnancy; dose adjustment may be needed during pregnancy and/or immed. postpartum; no known risk of fetal harm based on human data
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties; possible risk of delayed milk production based on conflicting human data
Pharmacology .
Metabolism: liver, kidney, fat; CYP450: none
Excretion: urine; Half-life: 81min; Info: onset, peak, duration vary among insulin products and routes; search Insulin Product Comparisons for more info
Subclass: Diabetes: Insulins
Mechanism of Action
stimulates peripheral glucose uptake, inhibits hepatic glucose production, inhibits lipolysis and proteolysis, regulating glucose metabolism (rapid-acting insulin)
Formulary .
No Formulary Selected
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