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Interaction Check

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Selected Drugs Clear All

  • remove Syeda
    drospirenone/ ethinyl estradiol
  • remove Theraflu Daytime Severe Cold Relief
    acetaminophen/ dextromethorphan
  • remove Tofranil
    imipramine
  • remove Tums Chewy Bites
    calcium carbonate

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Syeda (drospirenone/ ethinyl estradiol) + Theraflu Daytime Severe Cold Relief (acetaminophen/ dextromethorphan)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + acetaminophen

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

Smiley face Smiley face Theraflu Daytime Severe Cold Relief (acetaminophen/ dextromethorphan) + Tofranil (imipramine)

Monitor/Modify Tx


dextromethorphan + imipramine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Additional Considerations

Smiley face Smiley face dextromethorphan in Theraflu Daytime Severe Cold Relief

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face imipramine in Tofranil

add MAO inhibitor to Interaction Check if recent (14 days) use

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