Interaction Check

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MultiCheck Results - 2 Interactions

Monitor/Modify Tx
metoprolol succinate (generic) + pentazocine/naloxone (generic)
Monitor/Modify Tx metoprolol + pentazocine monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)
metoprolol succinate (generic) + Visine Red Eye Total Comfort Multi-Symptom (tetrahydrozoline/ zinc sulfate/ polyethylene glycol 400 ophthalmic)
Monitor/Modify Tx metoprolol + tetrahydrozoline ophthalmic consider monitoring BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)
Additional Considerations
pentazocine in pentazocine/naloxone
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use
naloxone (abuse deterrent) in pentazocine/naloxone
no pharmacologic activity when administered as directed
metoprolol in metoprolol succinate
avoid combo with beverages or products containing ethanol and metoprolol extended-release (ER) sprinkle; combo may incr. metoprolol release rate, levels, risk of adverse effects, decr. duration of efficacy