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Interaction Check

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Selected Drugs Clear All

  • remove Alka-Seltzer Plus Maximum Strength Cold & Flu Day PowerMax
    acetaminophen/ dextromethorphan/ phenylephrine
  • remove leucovorin
    generic
  • remove triamterene/ hydrochlorothiazide
    generic

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Alka-Seltzer Plus Maximum Strength Cold & Flu Day PowerMax (acetaminophen/ dextromethorphan/ phenylephrine) + triamterene/hydrochlorothiazide (generic)

Monitor/Modify Tx


phenylephrine + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

phenylephrine + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face leucovorin (generic) + triamterene/hydrochlorothiazide (generic)

Monitor/Modify Tx


leucovorin + hydrochlorothiazide

monitor calcium: combo may increase risk of hypercalcemia (additive effects, (levo)leucovorin injection contains calcium)

Additional Considerations

Smiley face Smiley face leucovorin

levoleucovorin is the active isomer of racemic leucovorin; similar interactions anticipated

Smiley face Smiley face phenylephrine in Alka-Seltzer Plus Maximum Strength Cold & Flu Day PowerMax

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Alka-Seltzer Plus Maximum Strength Cold & Flu Day PowerMax

add MAO inhibitor to Interaction Check if recent (14 days) use

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