Interaction Check

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MultiCheck Results - 3 Interactions

Avoid/Use Alternative
buprenorphine transdermal (generic) + Vicks DayQuil Severe Cold & Flu + Congestion w/ VapoCOOL (acetaminophen/ dextromethorphan/ phenylephrine/ guaifenesin)
Avoid/Use Alternative buprenorphine + dextromethorphan use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)
Vicks DayQuil Severe Cold & Flu + Congestion w/ VapoCOOL (acetaminophen/ dextromethorphan/ phenylephrine/ guaifenesin) + Zeposia (ozanimod)
Avoid/Use Alternative phenylephrine + ozanimod avoid combo w/in 14 days of ozanimod use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)
Monitor/Modify Tx
buprenorphine transdermal (generic) + valériane (valerian (Valeriana spp.))
Monitor/Modify Tx buprenorphine + valerian monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Additional Considerations
phenylephrine in Vicks DayQuil Severe Cold & Flu + Congestion w/ VapoCOOL
add MAO inhibitor to Interaction Check if recent (14 days) use
dextromethorphan in Vicks DayQuil Severe Cold & Flu + Congestion w/ VapoCOOL
add MAO inhibitor to Interaction Check if recent (14 days) use
buprenorphine in buprenorphine transdermal
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use