Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
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Mounjaro
(tirzepatide) + Simpesse
(levonorgestrel/ ethinyl estradiol) |
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Avoid/Use Alternativetirzepatide + ethinyl estradiol (contraceptive) monitor glucose if type 2 diabetes mellitus use; use alternative non-oral hormonal contraceptive or additional non-hormonal contraceptive x4wk after tirzepatide tx start and x4wk after each dose incr.: combo may decr. ethinyl estradiol levels, contraceptive efficacy; may decr. antidiabetic agent efficacy (absorption delayed, possibly decreased; antagonistic effects) tirzepatide + levonorgestrel (contraceptive) monitor glucose if type 2 diabetes mellitus use; use alternative non-oral hormonal contraceptive or additional non-hormonal contraceptive x4wk after tirzepatide tx start and x4wk after each dose incr.: combo may decr. peak levonorgestrel levels, contraceptive efficacy; may decr. antidiabetic agent efficacy (absorption delayed, possibly decreased; antagonistic effects) |
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Additional Considerations |
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tirzepatide
in Mounjaro
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caution advised with oral drugs, especially narrow therapeutic index; tirzepatide delays gastric emptying, may alter absorption of concomitant oral drugs |
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