aspirin + ibuprofen

avoid aspirin >325 mg/day; otherwise, use alternative or monitor bleeding s/sx, renal fxn; may give low-dose aspirin at least 2-4h before or at least 8h after single ibuprofen 400 mg dose: combo may incr. risk of GI ulceration, perforation, bleeding (including life-threatening), renal impairment, other adverse effects; ibuprofen may inhibit cardioprotective effect of low-dose aspirin (additive effects, duplicate therapy; possible competition for platelet binding sites)

caffeine + ibuprofen

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

aspirin + lecanemab

monitor bleeding s/sx: combo may incr. risk of intracerebral bleeding, including life-threatening (additive effects)