epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Lokelma
    sodium zirconium cyclosilicate
  • remove Lyrica
    pregabalin
  • remove Restoril
    temazepam

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Lyrica (pregabalin) + Restoril (temazepam)

Monitor/Modify Tx


pregabalin + temazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Additional Considerations

Smiley face Smiley face sodium zirconium cyclosilicate in Lokelma

separate administration from other oral drugs by at least 2h; sodium zirconium cyclosilicate may decr. absorption of concomitant oral drugs

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information