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Interaction Check

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Selected Drugs Clear All

  • remove hamamélis
    witch hazel (Hamamelis virginiana)
  • remove ibandronate
    generic
  • remove Lorcet Plus
    hydrocodone/ acetaminophen
  • remove Mucinex Fast-Max Kickstart Severe Cold & Flu All-in-One
    acetaminophen/ dextromethorphan/ phenylephrine/ guaifenesin
  • remove Pepto-Bismol LiquiCaps
    bismuth subsalicylate

multicheck MultiCheck Results - 4 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Lorcet Plus (hydrocodone/ acetaminophen) + Mucinex Fast-Max Kickstart Severe Cold & Flu All-in-One (acetaminophen/ dextromethorphan/ phenylephrine/ guaifenesin)

Avoid/Use Alternative


acetaminophen + acetaminophen

limit acetaminophen from all sources to standard max acetaminophen doses: combo may incr. acetaminophen levels, risk of hepatotoxicity, other adverse effects (additive effects, duplicate therapy)

hydrocodone + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

Smiley face Smiley face ibandronate (generic) + Pepto-Bismol LiquiCaps (bismuth subsalicylate)

Monitor/Modify Tx


ibandronate + bismuth subsalicylate

monitor bleeding signs/symptoms if oral ibandronate use: combo may incr. risk of upper GI ulceration, perforation, bleeding (additive effects)

Smiley face Smiley face Mucinex Fast-Max Kickstart Severe Cold & Flu All-in-One (acetaminophen/ dextromethorphan/ phenylephrine/ guaifenesin) + Pepto-Bismol LiquiCaps (bismuth subsalicylate)

Monitor/Modify Tx


phenylephrine + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Mucinex Fast-Max Kickstart Severe Cold & Flu All-in-One

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Mucinex Fast-Max Kickstart Severe Cold & Flu All-in-One

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face hydrocodone in Lorcet Plus

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy

Smiley face Smiley face ibandronate

administer oral ibandronate at least 1h before other oral drugs; combo may decr. ibandronate absorption, efficacy

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