Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Avoid/Use Alternative |
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Sinemet
(carbidopa/ levodopa) + Virtussin DAC
(codeine/ pseudoephedrine/ guaifenesin) |
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Avoid/Use Alternativelevodopa + codeine avoid combo if antitussive use; otherwise, monitor BP, respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects) |
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Monitor/Modify Tx |
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Rectiv
(nitroglycerin intra-anal) + Sinemet
(carbidopa/ levodopa) |
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Rectiv
(nitroglycerin intra-anal) + Virtussin DAC
(codeine/ pseudoephedrine/ guaifenesin) |
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Additional Considerations |
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levodopa
in Sinemet
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add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and Crexont; combo may incr. levodopa release rate, levels, risk of adverse effects, decr. duration of efficacy |
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carbidopa
in Sinemet
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avoid combo with beverages or products containing ethanol and Crexont; combo may incr. carbidopa release rate, levels, risk of adverse effects, decr. duration of efficacy |
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nitroglycerin
in Rectiv
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if SL nitroglycerin tab use, caution advised with anticholinergic drugs, tricyclic antidepressants, other drugs that may cause xerostomia; combo may delay vasodilator onset, decr. nitroglycerin peak levels, efficacy; absorption decreased, xerostomia may alter dissolution of SL tab |
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selumetinib
in Koselugo
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avoid supplemental vitamin E if daily vitamin E intake greater than recommended or safe limits; combo may incr. risk of bleeding; additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules |
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codeine
in Virtussin DAC
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use |
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pseudoephedrine
in Virtussin DAC
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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