morphine + prochlorperazine

consider alternative or monitor respiratory rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

ketorolac ophthalmic + ketoprofen

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

insulin + ethinyl estradiol (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

insulin + norethindrone (contraceptive)

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

insulin + levalbuterol inhaled

monitor potassium: combo may incr. risk of hypokalemia (additive effects)

ethinyl estradiol (contraceptive) + ketoprofen

monitor BP, thrombosis s/sx; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

norethindrone (contraceptive) + ketoprofen

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ketoprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

ethinyl estradiol (contraceptive) + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

ketoprofen + levalbuterol inhaled

monitor BP: combo may incr. risk of HTN (additive effects)

ketorolac ophthalmic + dexamethasone ophthalmic

caution advised: combo may slow or delay ocular wound healing (additive effects)