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Interaction Check

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Selected Drugs Clear All

  • remove bismuth subsalicylate
    generic
  • remove Junel 1.5/ 30
    norethindrone/ ethinyl estradiol
  • remove Tylenol w/ Codeine #3
    acetaminophen/ codeine

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Junel 1.5/30 (norethindrone/ ethinyl estradiol) + Tylenol w/ Codeine #3 (acetaminophen/ codeine)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + codeine

use alternative or monitor respiratory rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism inhibited, may alter production of active metabolite morphine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + acetaminophen

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

Monitor/Modify Tx

Smiley face Smiley face bismuth subsalicylate (generic) + Junel 1.5/30 (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


bismuth subsalicylate + ethinyl estradiol (contraceptive)

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face codeine in Tylenol w/ Codeine #3

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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