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Interaction Check

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Selected Drugs Clear All

  • remove Exparel
    bupivacaine liposomal
  • remove Tylenol w/ Codeine #4
    acetaminophen/ codeine

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Exparel (bupivacaine liposomal) + Tylenol w/ Codeine #4 (acetaminophen/ codeine)

Monitor/Modify Tx


bupivacaine liposomal + codeine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

Caution Advised


bupivacaine liposomal + acetaminophen

caution advised: combo may incr. risk of methemoglobinemia (additive effects)

Additional Considerations

Smiley face Smiley face codeine in Tylenol w/ Codeine #4

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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