Selected Drugs Clear All
MultiCheck Results
- 1
Interaction
Avoid/Use Alternative |
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Ogsiveo
(nirogacestat) + tramadol
(generic) |
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Avoid/Use Alternativenirogacestat + tramadol use alternative or monitor respiratory rate, ECG, consider decr. tramadol dose: combo may incr. tramadol and active metabolite levels, risk of CNS and respiratory depression, psychomotor impairment, seizures, serotonin syndrome, QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite) |
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Additional Considerations |
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tramadol
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use |
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