Selected Drugs Clear All
MultiCheck Results
- 4
Interactions
Avoid/Use Alternative |
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chlordiazepoxide/amitriptyline
(generic) + nalbuphine
(generic) |
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Avoid/Use Alternativeamitriptyline + nalbuphine use alternative or monitor respiratory rate, BP, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, other anticholinergic adverse effects (additive effects) chlordiazepoxide + nalbuphine use alternative or monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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nalbuphine
(generic) + S-adénosylméthionine
(SAMe) |
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Avoid/Use Alternativenalbuphine + SAMe use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects) |
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Monitor/Modify Tx |
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chlordiazepoxide/amitriptyline
(generic) + S-adénosylméthionine
(SAMe) |
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Monitor/Modify Txamitriptyline + SAMe monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects) |
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Additional Considerations |
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amitriptyline
in chlordiazepoxide/amitriptyline
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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nalbuphine
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use |
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